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doi: 10.2337/dc24-0764 [DOI] [PMC free article] [PubMed] [Google Scholar] 36.Vitorino R

Back pain is not listed as a common or characteristic adverse effect in the FDA-approved prescribing information for GLP-1 receptor agonists or the dual GIP/GLP-1 agonist tirzepatide

Wiehle R, Cunningham GR, Pitteloud N, Wike J, Hsu K, Fontenot GK, Rosner M, Dwyer A, Podolski J

It also explains why simply lowering insulin resistance whether through weight loss, metformin, or, hypothetically, an incretin-based agent can improve both the metabolic and the reproductive dimensions of the syndrome: reducing hyperinsulinemia lowers the drive to ovarian androgen production and restores some SHBG, which is the biological basis for the interest in any potent insulin-sensitizing intervention

From bench to bedside: The journey of tirzepatide from conception to clinical application