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Direct contact of nutrients with intestinal L-cells on the apical intestinal lumen produces an initial secretory peak as early as 1015 min after consumption of a meal, followed by a secondary peak around 3060 min post-consumption [11]

21 The introduction of Aib 2 into GIP has also been reported, and it seems that it does not obviously affect the cAMP activity

[1] Orforglipron is also chemically different from previous oral GLP-1s

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Regrowth initially appears as fine, sometimes lighter-colored baby hairs