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One used a diphtheria toxin-inducible -cell KO of Gcg and this mouse had a small impairment of age-induced IP glucose tolerance (227)

Avoid fried foods, sugary beverages, excessive alcohol, and large heavy meals that may worsen nausea and digestive symptoms

Yet it also brings challenges in access, regulation, and trust

doi: 10.1161/CIR.0000000000000920 77 PfefferMAClaggettBDiazRDicksteinKGersteinHCKberLVet al

For individuals with obesity and comorbid psychological symptoms, combined outcomes such as clinically significant weight loss (e.g., 10%) and reduced binge-eating frequency or depressive symptoms are reasonable targets