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Available from: 121.Buse J.B., et al

Psychiatry 15:1491417

Initial reports in animals showed that GLP-1 acutely increases blood pressure (BP) and heart rate (HR) in rats and mice, actions mediated through activation of the autonomic nervous system, including medullary catecholamine neurons, providing input to sympathetic preganglionic neurons (13)

That means millions of patients will soon potentially lose access to cheaper, but less regulated, alternatives to the brand name drugs

In a statement published alongside the results, Amgen said it used its genetic expertise to identify GIP receptor inhibition as a key factor in reducing body mass, an insight that led to MariTides development