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(2024) in different populations both exhibited significantly lower incidences of open-angle glaucoma in diabetic patient groups treated with GLP-1RAs medication compared with the control group

Discussion GLP-1/exendin-4 Suppresses GABA Currents of Rat GCs by Activating GLP-1R Although GLP-1 and GLP-1R agonists have been reported to regulate AMPA receptors and GABA A receptors in central neurons [14, 57,58,59,60], no data concerning the regulation of ligand-gated channels of retinal neurons by GLP-1/GLP-1R agonists were available

GPR119 GPR119, also known among other names as glucose-dependent insulinotropic receptor (GDIR), was independently discovered less than two decades ago by several groups around the world and deorphanized soon after with the discovery of Oleoylethanolamide (OEA) as its first endogenous ligand (314316)

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doi: 10.1016/j.bjps.2023.04.057 [DOI] [PubMed] [Google Scholar] 19