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The blazing success of weight loss drugs like Wegovy and Mounjaro has electrified the pursuit of new treatments for obesity

Abdominal Discomfort Abdominal discomfort, bloating, or indigestion can occur

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This suggests a functional dissociation between GLP-1 modulation of metabolic and drug-related appetitive processes [48]

However, it is unlikely that highly desirable more efficacious treatments will be developed for metabolic disorders until the complex systemic regulation of metabolic homeostasis becomes more intricately understood