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The starting dose and length of time to maintenance dose are critical to optimizing patient tolerability, Blai Coll, chief medical officer of Structure Therapeutics, told BioSpace

For instance, GLP-1RA have been tested in people with serious mental illness, who could be at a high suicidality risk, showing metabolic benefits with no increase in psychopathology or occurrence of SIS [22]

While human studies are still limited, the potential of GLP-1 medications to address the neurobiological underpinnings of addiction holds promise for developing novel pharmacological interventions and improving addiction treatment outcomes

Entry of exendin-4 into brain is rapid but may be limited at high doses

Regular exercise naturally boosts dopamine and endorphins