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Significant weight reduction ability of semaglutide has been demonstrated in various phase-3 clinical trials, for which recently semaglutide became the first long-acting GLP-1 receptor agonist to be approved by the United States Food and Drug Administration for management of obesity

GCs antagonize the metabolic effects of insulin, particularly in the postprandial state through the induction of enzymes that promote gluconeogenesis, increased lipolysis and proteolysis, increased mitochondrial activity, the enhancement of the effects of counterregulatory hormones, such as glucagon and epinephrine, and the induction of insulin resistance via the nuclear peroxisome proliferator-activated receptor (PPAR) [4,21,25]

Also, a meta-analysis on antidepressant effects of GLP-1 RA including 2071 participants showed reduced depression scores with GLP-1 treatment compared with controls [17]

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