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Heavy drinking increases pancreatitis risk independently and could potentially compound medication risks

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17 Accordingly, current clinical guidelines, including those from the American Association of Clinical Endocrinology (AACE) and European Association for the Study of Obesity (EASO), recommend pharmacological therapy for individuals with obesity or overweight accompanied by weight-related comorbidities

The oral vs injection comparison shows that efficacy appears similar in clinical studies, though oral formulations have their own considerations including specific fasting requirements and potentially different GI side effect profiles