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Autoimmune thyroid disease can be unpredictable, and the combination of weight loss and GLP-1 therapy may occasionally trigger changes in antibody levels or symptom severity

doi: 10.1016/j.neuropharm.2019.107668

Although the mechanism of this proposed uncoupling event has not been fully elucidated, our understanding of the GLP-1R signalling cascade suggests that SUs may allow GLP-1R agonists to bypass glucose dependence by triggering -cell depolarization even in the absence of glucose

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