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This happens partly because of weight loss but also because these medications reduce ectopic fat (unhealthy fat around organs) and decrease inflammation

You can take it with food or without food

Oxygen supplementation can have a similar stabilizing effect on the ventilatory drive, as increases in the partial pressure of oxygen can lower the bodys peripheral chemosensitivity and downregulate chemical loop gain [82]

Lei H, Gao Y, Xu X

For adults over 65, no dose adjustment is required, but careful monitoring for adverse effects is prudent as older adults often have multiple comorbidities and medications that increase complication risk