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[0022] A major hurdle in nasal delivery is the rapid removal of drug formulations (aqueous solution or dry powder) from the nasal cavity by rapid mucociliary beating, resulting in a clearance half-life of about 15 min for ordinary formulations, as well as low bioavailability (Merkus et al., 1998), especially for semaglutide and other polypeptides with high molecular mass and low diffusion rate across mucosal epithelium

GLP-1RAs and SGLT2is also provide sustained weight loss via different mechanisms

The group I feel most strongly about is the long-term yo-yo dieters

The Future of GLP-1 and GIP Agonists The beauty of science is that it always, relentlessly, marches forward

Both are developed to supplement your existing biology
