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This was based largely on the FLOW trial, which found that patients with CKD and Type 2 diabetes who took semaglutide had a significantly lower risk of major kidney events (kidney failure, dialysis, transplant)

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Protein provides the amino acid substrate necessary for muscle protein synthesis, and inadequate intake during weight loss directly accelerates sarcopenia
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Schubert MM, Astorino TA, Azevedo JL, Jr