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Established ASCVD was defined as MI, stroke, any revascularization procedure, transient ischemic attack, unstable angina, amputation, symptomatic or asymptomatic coronary artery disease

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However, doses of 120mg twice daily were shown to be more associated with the production of reduced appetite, dyspepsia and dizziness

CagriSema , the combination of cagrilintide and semaglutide, is another development showing promise, as detailed in the CagriSema dosing guide