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By improving insulin sensitivity, GLP-1 RAs may reduce hyperinsulinemia-driven androgen production and help restore ovulatory cycles.47, 48, 49 A meta-analysis in women with polycystic ovary syndrome and overweight or obesity found that GLP-1 RA use was associated with improvements in menstrual regularity (standardized mean difference: 1.72, 95% CI 0.60, 2.85) compared to metformin or placebo, and spontaneous pregnancy rate (RR: 1.72, 95% CI 1.22, 2.43) compared to metformin

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Add water slowly down the inner wall of the vial never directly onto the powder to avoid foaming and protein denaturation