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Wegovy (semaglutide 2.4 mg) is a glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity, as an adjunct to a reduced-calorie diet and increased physical activity

LIMITATIONS OF CURRENT EVIDENCE AND GAPS IN KNOWLEDGE Despite the increasing information on gut microbiota as a modulator of antidiabetic drug effects, there are still systematic and conceptual gaps in the data available

Gastrointestinal effects remain the most common complaint

doi: 10.15585/mmwr.mm6650a1 [DOI] [PMC free article] [PubMed] [Google Scholar] 15.Wright DR, Guo J, Hernandez I

In people without diabetes, DPP-4 breaks down incretin hormones to balance blood sugar and insulin levels