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[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

Although, most participants lost weight, there was heterogenicity, that has been well-documented in obesity studies [66] and those with higher BMI above 35 experienced greater mean percentage weight loss [64]

[DOI] [PubMed] [Google Scholar] 93.Xue M., et al

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Comprehensive programs incorporating: Nutritional counseling emphasizing gradual caloric reduction (500750 kcal/day deficit) Regular physical activity (150 minutes weekly moderate-intensity exercise) Behavioral therapy and support groups Slower weight loss targets (0.51 kg or 12 pounds weekly) This approach minimizes gallstone formation risk through gradual weight reduction while still achieving meaningful health benefits
