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Where short-term acting GLP-1RAs primarily exert their effects by modulating and delaying gastric emptying and subsequent changes in postprandial glucose uptake, longer-acting GLP-1RAs affect both basal and postprandial glucose regulation [42]

[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Cant C., Jiang L.Q., Deshmukh A.S., Mataki C., Coste A., Lagouge M., Zierath J.R., Auwerx J

[DOI] [PubMed] [Google Scholar] 73.Monami M, Dicembrini I, Nardini C, Fiordelli I, Mannucci E

as well as HPA-axis 172,173 which could affect stress and SNS

These compounds were initially developed for the treatment of type 2 diabetes (T2D), but many have proven weight loss benefits in randomized controlled trials among individuals without T2D