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Less volume means less injection site discomfort, faster absorption, and smaller fluid deposits under the skin

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Today, fewer than 1 in 10 people who could benefit from a GLP-1 are taking one, held back by access, stigma, perceived complexity or the belief that their condition isnt serious enough for treatment, said David A Ricks, chair and CEO of Eli Lilly, in a statement

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Compared to the active state, ECL1 moves toward helix I by 5 when measured at the N-terminal tip of the helix (C of Q211), and ECL1 residue W214 is reoriented ~180 o from an outside-facing position to a position pointing towards helix I