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Efficacy and safety of novel twincretin tirzepatide a dual GIP and GLP-1 receptor agonist in the management of type-2 diabetes: A cochrane meta-analysis

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Maryland's stakeholder council heard an overview by Brian Link of Three Axis Advisors about drug pricing and the supply chain

In the Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron produced mean body weight reductions of 7.5% (6 mg), 8.4% (12 mg), and 11.2% (36 mg) at 72 weeks, compared with 2.1% for placebo

GLP-1/GIP peptide (Tirzepatide) has also been FDA-approved for treating type-2 diabetes