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P., Holst, A

Biological characteristics of GLP-1RAs Molecular structure and pharmacological properties Due to the suboptimal in vivo stability of the native GLP-1 peptide, GLP-1RAs were engineered with structural modifications that mimic endogenous GLP-1 while achieving a prolonged duration of action [15]

It was evident that retatrutide showed clinically meaningful improvements in glycaemic control and impressive reductions in body weight in type 2 diabetic patients while being relatively safe

Ileal instillation of carbohydrate or lipid induced a more rapid stimulation of GLP-1 (63)

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