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During the treatment of RA, NPs, GLP-1RAs@NPs or GLP-1RAs@NPs-WYRGRL were injected subcutaneously into the skin of the hind paws of rats, or MN and MN/GLP-1RAs@NPs-WYRGRL were used to puncture the skin and left in place

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Monthly visits during dose titration: weight check, side effect review, dose adjustment
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