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128 caution is still recommended in patients with predisposing risk factors or a history of pancreatitis

doi: 10.1056/NEJMoa2307563 [DOI] [PubMed] [Google Scholar] 200

These are the same eligibility criteria embedded in the FDA-approved indications for semaglutide and tirzepatide for chronic weight management

Mordi IR, Singh S, Rudd A et al (2018) Comprehensive Echocardiographic and Cardiac Magnetic Resonance Evaluation Differentiates Among Heart Failure With Preserved Ejection Fraction Patients, Hypertensive Patients, and Healthy Control Subjects

The company describes the formulation as designed to support the body's internal metabolic signaling pathways through gut microbiome support