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In the head-to-head comparison between tirzepatide and semaglutide, the two drugs yielded similar risks for component endpoints all-cause mortality (HR 1.03, 95% CI 0.84 to 1.27), myocardial infarction (HR 1.03, 95% CI 0.88 to 1.21) and stroke (HR 1.15, 95% CI 0.92 to 1.45) (Fig
However, despite the intensive treatment, the STEP 3 trial did not achieve better weight loss outcomes than those of the STEP 1 trial in which semaglutide 2.4 mg was combined with a less-intensive lifestyle intervention program (i.e., 18 behavioral counseling visits every 4 weeks in 68 weeks) and no initial low-calorie, meal-replacement diet (253)
They're also less likely to have non-responders and late-responders
Association of GLP-1 receptor agonists and hepatocellular carcinoma incidence and hepatic decompensation in patients with type 2 diabetes
Sterile water lacks this preservative
