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10.1146/annurev-immunol-042617-053335 6 BenN

However, people without gallbladders may experience more pronounced digestive side effects when starting GLP-1 therapy because their bile flow is already compromised and semaglutide adds another layer of digestive slowing

For the estimated 25 to 35 percent of prospective GLP-1 patients who cite needle aversion as a primary barrier to starting treatment this format is clinically meaningful
