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Who Should Not Use GLP-1 Medications According to standard clinical guidelines and prescribing information, GLP-1 medications may not be appropriate for individuals who: Have a personal or family history of medullary thyroid carcinoma Have multiple endocrine neoplasia syndrome type 2 Have a history of pancreatitis Have severe gastrointestinal disease (gastroparesis, inflammatory bowel disease) Are pregnant, planning to become pregnant, or breastfeeding Have a history of severe allergic reactions to semaglutide, tirzepatide, or any inactive ingredients This is not a replacement for prescribed medical treatment for any health condition

The PlexusDx Precision Peptide Genetic Test analyzes variants in GLP1R, GIPR, FTO, and MC4R genes plus 10 additional pathways to predict how your body responds to semaglutide and tirzepatide

Rhythm also announced that it has initiated a Part D arm in the Phase I trial of MC4R agonist RM-718 that will enroll up to 20 patients with PWS

[DOI] [PubMed] [Google Scholar] 58.Yuen J.W.Y., Kim D.D., Procyshyn R.M., Panenka W.J., Honer W.G., Barr A.M

First, some of the muscle change happens with any rapid weight loss, and a portion may be a normal adjustment to a smaller body rather than harmful wasting (Mocciaro and colleagues, BMJ Nutrition Prevention and Health , 2025)