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Ozempic ROI vs Metformin While Ozempic carries a higher price tag, its greater efficacy for weight loss and cardiovascular risk reduction may justify the investment for certain patients

We are in a new era for obesity pharmacotherapy where combinations of entero-pancreatic hormones approach the WL achieved with bariatric surgery

J Clin Endocrinol Metab 39: 223228

G., Balthasar, N., Heisler, L

Adding GIPR co-agonism (as in tirzepatide and retatrutide) introduces additional Gs signalling from a second receptor type expressed on adipocytes, beta cells, and hypothalamic neurones
