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Mol Psychiatry 28(1):217229 Paz-Filho G, Mastronardi CA, Licinio J (2015) Leptin treatment: facts and expectations

Immediate medical attention is necessary if patients experience: Severe abdominal pain radiating to the back Pain accompanied by persistent vomiting Symptoms of pancreatitis Signs of severe dehydration Inability to keep food down Research indicates that stomach-related side effects typically follow a predictable pattern
These benefits may ultimately prove more important than weight loss percentages for overall health outcomes

The health implications of these results are profound (1)
The journey, however, can be different for men and women