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Given the observed increased risk of colorectal cancer among patients receiving GLP-1 receptor agonists, clinicians should approach long-term prescribing of these agents with careful consideration, particularly in individuals with additional risk factors for colorectal cancer, such as a family history, obesity, inflammatory bowel disease, or long-standing type 2 diabetes

Dose Escalation Structure Phase Weekly Dose Weeks 14 1 mg Weeks 58 2 mg Weeks 912 4 mg Maintenance (research range) 68 mg Clinical trials have evaluated doses up to 12 mg once weekly with gradual titration

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