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Glycemic control & metabolic health: Research focused on glucose tolerance, insulin dynamics, hepatic glucose output and broader metabolic homeostasis in preclinical systems

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SCALE Obesity and Prediabetes NN80221839 Study Group

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Semaglutide is FDA-approved, globally available, and backed by 25,000+ trial participants and 7+ years of real-world data

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Metformin is associated with higher relative abundance of mucin-degrading Akkermansia muciniphila and several short-chain fatty acidproducing microbiota in the gut

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Vitamin A derivatives (retinol and all-trans-retinal) and several products of the tryptophan metabolic pathway, including l-kynurenine (L-KYN), 3-hydroxykynurenine (3-HK), 3-HA, and serotonin (5-HT), have all been identified as effective RTAs (50, 75, 95, 96)

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