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Jim List, Pfizers Chief Internal Medicine Officer, said

Ryan DH, Lingvay I, Deanfield J, Kahn SE, Barros E, Burguera B, Colhoun HM, Cercato C, Dicker D, Horn DB, Hovingh GK, Jeppesen OK, Kokkinos A, Lincoff AM, Meyhfer SM, Oral TK, Plutzky J, van Beek AP, Wilding JPH, Kushner RF

Individuals with diabetes are already predisposed to vascular complications so introducing semaglutide to the mix could cause such an injury

GLP-1 receptor agonists stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning they only promote insulin release when blood glucose levels are elevated

However, both medications warrant routine cardiovascular monitoring, and women with a personal or family history of clotting disorders should discuss their risk profile with their provider before starting semaglutide