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First off, we know that the GLP-1 receptor agonists act on receptors in the brain any drug that can get across the blood brain barrier, in theory, can have adverse (or positive) psychiatric effects

This review article is based on previously conducted studies and does not contain studies with human participants or animals performed by any of the authors

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In the ACHIEVE-3 head-to-head against oral semaglutide in T2D, 36 mg orforglipron produced about 9.2% body weight reduction versus about 5.3% on 14 mg oral semaglutide, and superior HbA1c reduction

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