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Early trials, concerned about possible cardiac safety issues, were designed to ensure that GLP-1 use did not negatively impact cardiovascular outcomes

The cardiovascular outcome data alone, covering nearly 100,000 patients in randomized trials, places this class among the most impactful drug discoveries in modern preventive medicine

However, no head-to-head comparisons of GLP-1RAs and other non-insulin glucose-lowering medications exist for patients with NAFLD and type 2 diabetes

Research into the compound's in vitro binding kinetics, receptor selectivity, and downstream signalling cascades continues to expand the understanding of multi-receptor incretin pharmacology

The team explored several pathways, including the PI3K/Akt pathway, which affects pancreatic duodenal homeobox 1 (PDX1) and Forkhead box O1 (FoxO1) transcription factors, essential for cell proliferation