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GIP and GLP-1, however, can be inactivated in vivo within minutes by dipeptidyl peptidase IV (DDP-IV) [4]
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In pancreatic beta cells, GLP-1RA promotes the conversion of proinsulin to mature insulin by upregulating the expression of hormone converting enzymes PC1/3 and PC2, while reducing the proinsulin/insulin ratio and enhancing insulin biological activity
