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This is a well-established physiological phenomenon that occurs regardless of the weight loss method employed

A 2025 study published in Diabetes, Obesity and Metabolism followed 106 patients on semaglutide 2.4mg for 12 months

Case Overview Ozempic is a GLP-1 agonist drug intended to treat diabetes

Abbreviations AACE/ACE: American Association of Clinical Endocrinologists/American College of Endocrinology ADA: American Diabetes Association ASCVD: Atherosclerotic cardiovascular disease AUC: Area under the curve C avg : Average plasma concentration CI: Confidence interval C max : Maximum concentration CV: Cardiovascular CVD: Cardiovascular disease CVOT: Cardiovascular outcomes trial DPP-4: Dipeptidyl peptidase-4 empa: empagliflozin ETD: Estimated treatment difference FDA: Food and Drug Administration GI: Gastrointestinal GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist GRAS: Generally regarded as safe HbA 1c : Glycated hemoglobin HR: Hazard ratio imp.: impairment lira: liraglutide MACE: Major adverse cardiovascular events met: metformin OAD: Oral antidiabetes drug pbo: placebo s.c.: subcutaneous sema: semaglutide SGLT2i: Sodium-glucose co-transporter-2 inhibitor sita: sitagliptin SNAC: Sodium N-(8-[2-hydroxybenzoyl]amino)caprylate SU: Sulfonylurea t 1/2 : Terminal half-life T2D: Type 2 diabetes T max : Time to maximum concentration References Lau JL, Dunn MK

Stress Levels Chronic stress can contribute to overeating, cravings, and slower progress