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Healthcare providers may suggest the following strategies: Stay hydrated: Aim for regular water intake and replenish fluids after gastrointestinal side effects

Apr 2026 Orforglipron (Foundayo), the first oral small-molecule GLP-1, wins approval for obesity in the fastest new-drug clearance since 2002
TGR5 and Its Physiologic Effects Relevant to GLP-1 and Glycogen Metabolism Takeda G protein-coupled receptor 5 (TGR5), a G protein-coupled bile acid receptor, contributes to improved hepatic insulin sensitivity and subsequent energy metabolism and homeostasis [139]

doi: 10.1016/J.MAD.2021.111473

Liu, L., et al
