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SGLT2 inhibitors provide substantial benefits for people with type 2 diabetes mellitus and either established HF or elevated HF risk [86]

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To prolong these effects therapeutically, GLP-1 RAs were designed to resist rapid degradation, allowing these medications to remain active in the human bloodstream for days

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GLP-1 medications can be used with other diabetes medicines, but there are special risks to consider: When GLP-1 medications are combined with insulin or medicines called sulfonylureas or meglitinides (which also lower blood sugar), the risk of low blood sugar (hypoglycemia) is higher

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