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Since metformin is known for its relatively benign adverse effects, it could be prescribed from the treatment onset along with the orexigenic PTDs

When estrogen levels drop, bad cholesterol (LDL and triglycerides) tends to rise, good cholesterol (HDL) can fall, and insulin resistance increases, she says

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Therefore, clinicians should adopt preemptive approaches, striving to avoid or delay the onset of obesity, and the metabolic syndrome instead of correcting them post hoc (7)

The other authors report no conflicts of interest