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Retailers: The Walmart findings suggest that retailers could also see a reduction in the total amount of food purchased by customers, although other retailers, such as Kroger, expect this to be more of a change in the types of food purchased, rather than an overall reduction in basket size

The study had some limitations

FDA Concerns Surrounding Compounded GLP-1 In a May 16, 2025 statement, the U.S

The Phase 2 trial indicated that retatrutide is similar in terms of safety and side effects to tirzepatide and semaglutide, and the TRIUMPH-1 Phase 3 trial confirmed a manageable safety profile at all doses tested

[46] The activation of central neuronal GLP-1 receptors by semaglutide signals through the endogenous opioid and adrenergic systems to suppress peripheral inflammation