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108 It is now understood that in addition to neuropathy of the enteric nervous system, the pathogenesis also involves a loss of interstitial cells of Cajal, enteric glial cell dysfunction, oxidative stress and inflammation

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While this chemical interaction calms intense cravings, it may also quell more joyful and less harmful wants a quieting of the wanting mind like the joy of eating a meal with family

constipation was experienced by about a quarter of patients in that group, as were diarrhea and vomiting