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Beyond weight loss, 73.5% of participants achieved hemoglobin A1c levels at or below 6.5%, compared to just 15.9% in the placebo group

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However, certain factors increase aspiration risk and may warrant additional precautions: Higher-risk features include : Recent initiation or dose escalation of Mounjaro Active gastrointestinal symptoms (nausea, vomiting, reflux) Known gastroparesis or autonomic neuropathy Higher maintenance doses (10 mg or 15 mg weekly) Concurrent opioid use or chronic kidney disease Procedures with higher aspiration risk For higher-risk patients , management options may include: A 24-hour clear liquid diet before surgery Point-of-care gastric ultrasound assessment if available Managing as a 'full stomach' with appropriate anaesthetic technique In some cases, considering postponement if in active dose escalation with significant symptoms For emergency or urgent surgery , stopping Mounjaro in advance is not possible

If the pen is not used within 21 days of being at room temperature, it should be discarded even if the printed expiration date has not passed

It is important to talk to your doctor about the risks and benefits of taking both medications together