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It generally appears as a pink or red spot at the injection site and dissipates within a few hours

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The main enzyme involved, dipeptidyl peptidase-4 (DPP-4) also known as CD26, cleaves off the two N-terminal residues resulting in GLP-1 (9-36 amide) which is inactive or acts as an inhibitor at the GLP-1 receptor (23)

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No statistically significant differences were observed between GLP-1 RA and DPP-4i users for atopic dermatitis, vitiligo, dermatomyositis, alopecia areata, lichen planus, cutaneous lupus erythematosus, hidradenitis suppurativa, systemic sclerosis, pyoderma gangrenosum, or morphea