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PMID: 37905277

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This growth trajectory is propelled by extensive label expansions, expanding payer coverage, and broadening clinical-guideline endorsements that position glucagon-like peptide-1 (GLP-1) agonists as first-line or early combination choices in diabetes, obesity, and cardiovascular risk reduction

When butyrate is in short supply, those cells weaken and small gaps can form, making it easier for unwanted substances to trigger irritation and inflammation over time

Real-world data from a comprehensive US Veterans Affairs Health Care system study of 215,970 individuals with type 2 diabetes revealed that GLP-1 medications were associated with reduced rates of neurocognitive disorders, including Alzheimers disease (HR 0.88) and dementia (HR 0.92), as well as decreased risks of substance use disorders and seizures [122]
