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Metformin and the gut microbiome The gut microbiome and the metagenome (the microbial genome) are areas receiving increasing research attention, and are now considered as environmental factors that contribute to the development of many diseases, including obesity, the metabolic syndrome and type 2 diabetes [7884]

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The outlook for the market remains positive, supported by rising health awareness, expanding reimbursement frameworks, and sustained technological advancement

In the clinical trial program, pancreatitis was reported in 15.2 cases per 10,000 patient year exposure while being treated with linagliptin compared with 3.7 cases per 10,000 patient year exposure while being treated with comparator (placebo and active comparator, sulfonylurea)

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