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At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems

We found that GLP-1 receptor agonists were associated with a lower risk of age-related macular degeneration (especially dry AMD) in adults with diabetes and obesity compared with metformin or other weight-loss medications

Viking Therapeutics stock more than doubled on Tuesday following the release of trials results suggesting its injectable obesity treatment outperforms industry leaders like Novo Nordisks Wegovy and Eli Lillys Zepbound.

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