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This suggests that while pharmacotherapy amplifies initial outcomes, structured exercise is strongly associated with more durable weight-loss maintenance

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Of note, even before the introduction of the newer classes of medications, multifactorial, target-driven therapies addressing glycaemic, blood pressure and lipid control that incorporated reninangiotensin system blockade, the use of statins and attention to lifestyle factors significantly reduced the progression to end-stage kidney disease by about 50% in people with type 2 diabetes, hypertension and microalbuminuria

van Raalte DH, Bunck MC, Smits MM, Hoekstra T, Corner A, Diamant M, et al

The EMA reported that semaglutide users faced more than double the risk of developing NAION compared to patients on other diabetes medications and recommended updating drug labels to reflect this risk