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Due to sequence similarities between GLP-1 and GIP, a chimera peptide of GLP-1 residues and certain C-terminal residues of GIP activates both the GLP-1 and GIP receptor (GIPR) [91]

J Neurosci 31:65876594

PlexusDx supports this informed decision-making through accessible genetic testing and evidence-based product options

For patients currently seeking treatment for obesity or type 2 diabetes in the UK, NICE-approved options include structured lifestyle interventions, orlistat, and more recently semaglutide (Wegovy, NICE TA875) and tirzepatide (Mounjaro, NICE TA1026) for eligible patients through NHS specialist weight management services

But, they also affect other systems, including the biliary system