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In contrast, recommendations for treatment selection in the second-line setting have been outlined in international guidelines, such as the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) guidelines, which inform choice of treatment according to an individuals CV and chronic kidney disease (CKD) risk [15]

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93 Based on mouse models, where the glucagon gene was disrupted by the insertion of green fluorescent protein, abolishing the synthesis of its products, including GLP-1

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