is yerba mate a glp-1 agonist Natural Support Organic Herbal Tea Blend 4 oz Blend : Grocery & Gourmet Food Does Yerba Mate Release GLP-1?

This is well documented

Receptor pharmacology studies suggest that tirzepatide engages the hGIPR in a manner similar to GIP but displays biased signaling at the GLP-1R to favor cAMP generation over beta-arrestin recruitment (Figure 2) 4749

X-ray crystallography revealed that each monomer consists of: An 8-bladed -propeller domain (residues 61-495, colored green), which contains two substrate anchoring residues, Glu205, Glu206 (colored cyan) An / hydrolase domain (residues 39-55 and 497-766, colored magenta), which contains three catalytic residues, Ser630, His740, Asp708 (colored orange) The domain organization of the DPP-4 dimer is shown in Figure-2 and a view of the enzyme active site is shown in the inset

They still work somewhat even after long-term use

Mounjaro/Zepbound (tirzepatide) is a GLP1/GIP dual agonist (~2022.5% loss)