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54 Since Epac2 mediates stimulatory effects of GLP-1 on Ca 2+ influx and mobilization, 49,91,101103 it appears that plasticity exists in the -cell cAMP signaling network such that the HFD leads to an unexpected coupling of glucose metabolism to Epac2 activation and insulin secretion

The distinct MHC-unrestricted immunobiology of innate-like and adaptive-like human T cell subsets-Natures CAR-T cells

doi: 10.1016/j.eclinm.2023.101865 15 YammineLde DiosCSuchtingRGreenCENielsenDAWalss-BassCet al

The current American College of Rheumatology (ACR) criteria for FM diagnosis require the presence of chronic widespread pain for at least three months and assessment of patient symptom burden using the Widespread Pain Index (WPI) and Symptom Severity Scale (SSS)

Pharmacologic Properties and Safety Table 3